EMCrit RACC-Lit Review for December 2024
4 hours ago
The more you give,The more you get
Q: What's in Prothrombin Complex Concentrate?
Q: Has there been a definitive trial to say PCC is better than FFP?
Q: Who should get PCC and who should get FFP?A: Any answer is going to be arbitrary and it’s mostly a matter of, “Do you have a few hours or do you need anticoagulation now?” It’s based on clinical judgement. PCC will make reversal happen much more quickly but may have a higher thromboembolic (TE) risk. There isn’t much data on the safety profile of PCC, but there is a small yet quantifiable TE risk. A recent meta-analysis found 1.8% risk of TE for 4 factor PCC and 0.7% for 3 factor PCC.
Q: Say you have someone who is having a life threatening bleed. What’s going to be the difference between giving 1mg and 10mg of vitamin K?The response to vitamin K is as variable as response to warfarin - meaning it’s not an exact science. Why 10mg rather than 1 mg? One mg of vitamin K will get patients back to therapeutic INR, but that’s not what we want in a life threatening bleed. Full reversal probably happens around 2-2.5 mg of vitamin K. Humans are variable in their response to vitamin K and the 10 mg dose is somewhat arbitrary. Some places give 5mg, others give 10mg. If you are in a situation where you do not want want to skimp on reversal, 10mg will fully reverse warfarin anticoagulation. But could you be faulted for giving 5mg? No. It is more a matter of making absolutely sure there is going to be full reversal, no questions asked. My recommendation, in life threatening bleeding, which more often than not is an intracranial bleed, give 10mg IV over 1 hour.
Time since last heparin dose | Dose of Protamine |
< 30 minutes | 1 unit/100 units of heparin |
30-60 minutes | 0.5 - 0.75 units/100 units of heparin |
60-120 minutes | 0.375 - 0.5 units/100 units of heparin |
> 120 minutes | 0.25 - 0.375 units/100 units of heparin |
1 unit of pheresis platelets
2 units of FFP
10 units of cryoprecipitate
Rove Beetle |
Class : Insecta |
Order : Coleoptera |
Family : Staphylinidae |
Species : Paederus fuscipes Curtis |
Semut Semai, Semut Kayap, Charlie etc. |
Estimated 47,000 |
The Rove Beetle is less than 1 cm long. The body is dark orange and the tip of the abdomen, the upper abdomen and the head are black. The upper middle iridescent greenish region of the abdomen are the hard wings (elytra). A pair of transparent wings are neatly folded and hidden under the hard wings. During daytime, the beetle will be seen crawling around swiftly with hidden wings resembling ants. When disturbed it raises the abdomen in a threatening gesture like a scorpion and can fly away. It can also run on water swiftly !
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Habitat and Feeding Habit | |||
The beetle has been observed in the paddy fields (since 1919), school fields - within the grass etc. It is carnivorous and eats smaller insects. Thus it plays an important role as a biological control of ‘paddy pests’. During heavy rains/ floods, the beetle may migrate to drier areas.
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The haemolymph in the beetle’s entire body (except the wings) contains the most poisonous animal contact toxin in the world called ‘pederin’ (C24 H43 O9 N) named in 1953. It is 12 times more poisonous than cobra venom ! Dried and stored rove beetle for 8 years still retained it’s toxicity ! Contact collision with the beetle while travelling or sleeping, crushing it on the body orsmearing with soiled fingers can cause conjunctivitis and severe dermatitis known as dermatitis linearis, paederus (rove beetle /staphylinidae) dermatitis, whiplash dermatitis etc. In September 2002 an epidemic of dermatitis linearis caused by rove beetles affected thousands of high rise flat dwellers and dormitory students in Penang, Malaysia.
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Since the beetle is attracted to lights at night, switch off or minimise the lighting and close doors/ windows during the beetle epidemic. Use fine mosquito netting, aerosol insect spray, glue traps etc. Do not sit near lights, do not smash the beetle on the body, just blow it away ! If there is contact with the beetle, immediately wash the affected area with soap and water. Those who suffer severe skin reactions should seek medical attention.
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