Friday, February 10, 2012

Anti-emetic Drugs

Monday, February 6, 2012

Datura (Buah kecubung) Toxicity

All Datura plants contain tropane alkaloids such as scopolamine, hyoscyamine, and atropine, primarily in their seeds and flowers. Because of the presence of these substances, Datura has been used for centuries in some cultures as a poison and hallucinogen. There can be a 5:1 toxin variation across plants, and a given plant's toxicity depends on its age, where it is growing, and the local weather conditions. This variation makes Datura exceptionally hazardous as a drug. In traditional cultures, a great deal of experience with and detailed knowledge of Datura was critical in order to minimize harm. Many tragic incidents result from modern recreational users ingesting Datura. For example, in the 1990s and 2000s, the United States media contained stories of adolescents and young adults dying or becoming seriously ill from intentionally ingesting Datura. There are also several reports in the medical literature of deaths from Datura stramonium and Datura ferox intoxication. Children are especially vulnerable to atropine poisoning, and their prognosis is likely to be fatal. In some parts of Europe and India, Datura has been a popular poison for suicide and murder. From 1950–1965, the State Chemical Laboratories in Agra, India investigated 2,778 deaths that were caused by ingesting Datura.

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Fever without a source (29 days-3 months old)

Source:http://academiclifeinem.blogspot.com/2012/02/paucis-verbis-fever-without-source-29.html

Gustilo open fracture classification

The most commonly used classification system for Open fractures. Created by Ramon Gustilo and Anderson, then further expanded by Gustilo, Mendoza, and Williams. This system uses the amount of energy, the extent of soft-tissue injury and the extent of contamination for determination of fracture severity. Progression from grade 1 to 3C implies a higher degree of energy involved in the injury, higher soft tissue and bone damage and higher potential for complications. Important to recognize that grade 3C fracture implies vascular injury as well.

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Was established since 25 Nov 09.Just to educate myself.

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